Substitute for Friday

Sorry I'm out - you'll have to learn on your own today...

on P.66, draw the diagrams for these three x-linked inheritance patterns:
Dominant, Affected father, unaffected mother
Recessive, unaffected father, affected mother
Recessive, unaffected father, carrier mother
(click on this link and scroll down a page for a sample)
http://en.wikipedia.org/wiki/Sex_linkage

...and then write a quick paragraph report describing the symptoms and treatments (if any) for any one of the known sex-linked examples (scroll farther down the same page)
or just click here:  http://en.wikipedia.org/wiki/Sex_linkage#X-Linked_Dominant_Inheritance

Substitute today

Keep working with your group on the seX-linked traits questions (pp.63-65), and have them completed at the end of the period.

63 64 65 seX-linked Traits

63 we listed some facts about sex-linked traits, get the notes in class or just look it up online
64 & 65 we practiced doing some test crosses to see how the results affected males and females, we looked at fruit fly eye color, human hemophilia, and calico cats...

(after spring break) 62 Function Finders (what do those genes/proteins do?)

So now we're getting pretty good at figuring out how proteins are made from genes in our DNA
(Still need help, here's another good tutorial)  -->  DNAtoPROTEIN

But how do we keep track of what each protein does? (and do they do the same thing in all species?)
We have specialized online databases for tracking the (thousands of) genes and proteins we know about.

In this activity, you'll be coding some very interesting proteins, searching an online database, and figuring out how they are relevant, and of course, recording your findings in your notebook, and sharing with the class...
The links: 
Handouts:  http://www.yourgenome.org/downloads/pdf/teachers/functionfinders/web_activity_sheet.pdf
ReLate Database:  http://www.ebi.ac.uk/training/schools/relate/
Protein Profiles:  http://www.yourgenome.org/downloads/pdf/teachers/functionfinders/protein_profiles.pdf

One new twist - the Amino Acid chart is based on the DNA this time, not the mRNA...  cool, and make sure you get a copy for your notes!  --> DNAcodonWHEEL

61 Progress Report

We'll post our progress reports here when we return from break, and get mom/pop/guardian signatures and do our reflections too.

55 56 57 58 59 60 CATTACA (rhymes with GATTACA)

Genetic Engineering.  Changing our (or something else's) DNA.

Creating a Genetically Modificed Organisms (GMO)

It's a big deal, and we as a society will need to make some important decisions regarding the ethics of changing the DNA of organisms...should we or shouldn't we?

But first, let's try the process on a CAT (why those letters???)
p.55 = Figure out what traits you want in your CAT, and make your order with a partner
p.56 = follow the lab instructions
p.57 = get the amino acid sequences for the proteins that will provide your traits
p.58 = figure out the mRNA codons for the amino acid sequences
p.59 = fill it out,

• #1 = traits, 
• #2 = amino acid sequences (from p.57), 
• #3 = mRNA for amino acids (from p.58), 
• #4 = add in the stop codons and make some long RNA strands, 

p.60

• #5 = make the DNA strand, 
• #6 = make the complementary strand of DNA

Now it's a good time to watch the movie GATTACA, not just because it's a great movie about how genetic engineering might affect our society, but also because you now know a lot about the underlying science!!!

54 Have your DNA and Eat It Too part 2 (DNA-->RNA-->Protein)

Using strands one and two together from the first part of this lab (pp.48-49), we will

TRANSCRIBE DNA-->RNA

TRANSLATE RNA-->Protein

Follow the instructions, use the marshmallows, and have fun!